Notably, pro-inflammatory cytokines like IL-6 and IL-8 have been recognized as contributors to this acceleration (Saparov et al., 2016; Heo et al., 2011) Similarly, AD-MSCs subjected to pre-treatment with lipopolysaccharides (LPS) have demonstrated their potential in promoting wound healing and angiogenesis, coupled with an increased release of growth factors associated with tissue regeneration and immune responses (Wang et al., 2022). The gene discussed is IL6; the disease is Alzheimer disease.