ACE2 and infection: SARS-CoV-2 is an enveloped virus with an RNA (+) genome, whose process of cellular infection occurs via binding of the viral spike protein (S) to the host receptor, angiotensin-converting enzyme 2 (ACE2), and its cleavage by transmembrane serine protease 2 (TMPRSS2) into the S1 and S2 subunits, allowing viral entry into the host cell (Benetti et al., 2020; Lieberman et al., 2020).