Being an essential protein for SARS-CoV-2 cell entry and viral dissemination (Hoffmann et al., 2020; Ni et al., 2020), high TMPRSS2 expression levels before infection observed in this study could indicate easier and faster viral replication and dissemination (Figure 5A), which might reflect in the manifestation of symptoms caused by the rapid dissemination of SARS-CoV-2 within human tissues. The gene discussed is TMPRSS2; the disease is infection.