ACE2 inhibition didn ́t show promising results, since it could have several side effects given its crucial role in human homeostasis (Donoghue et al., 2000; Santos et al., 2017; Shin et al., 2022), and with the results presented in this manuscript where lower ACE2 levels appeared to be a risk factor for symptomatic COVID-19, inhibiting ACE2 probably wouldn’t be of much help. Here, ACE2 is linked to COVID-19.