Met, mmp13, il12b, il4, and ptgs2 were regulated by jun and spil. Met, mmp13, and il12b were simultaneously regulated by il6. Ctsl, ptgs2, and il4 were regulated by jun and c3. In addition to jun, c3, and spil, il6 was has been shown to be involved in inflammatory and immune system diseases, where il6 acted not only as a TF but also as a target gene regulated by a TF. The gene discussed is IL6; the disease is immune system disorder.