In addition, the most significant 10 pathways were associated with immune-related diseases, including S. aureus infection (Dusane et al., 2018), leishmaniasis (Jaton et al., 2016; Cui et al., 2017), rheumatoid arthritis (Insa et al., 2017), and tuberculosis (Ashtekar et al., 2016); however, immune-related TFs and information pathways, including the chemokine signaling (Joanna et al., 2017) and TNF signaling (Nandi et al., 2017) pathways, were closely associated with other diseases. Here, TNF is linked to rheumatoid arthritis.