NFKB1 and rosacea: It is suggested that this mode of action explains why ivermectin may be helpful in intensive care unit settings with increased risks of LPS-mediated bacterial infections [50]. Ali et al. demonstrated that increased levels of IL-17 in rosacea led to the production of proinflammatory cytokines such as IL-1 and TNFα through the nuclear factor kappa-light-chain enhancer of activated B (NF-κB) pathway, which is again inhibited by ivermectin [51].