The study could be expanded to include a larger sample size; (b) only one polymorphic marker was selected based on an extensive text-mining approach; however, there are numerous other polymorphisms in the TLR4 gene that could show a positive association with OSCC; and (c) the study results were not stratified based on age, gender, or tumor grade owing to a small sample size. The gene discussed is TLR4; the disease is neoplasm.