Spearman correlation analysis was utilized to calculate the associations between 19 shared genera or 61 co-differential metabolites and indices related to HF (AST, ALT, ALP, liver index, and mRNA expression of IL-1β, IL-6, TNF-α, COL1a1, and α-SMA), as well as mRNA expression of TJPs (Claudin-1, Occludin, and ZO-1). This evidence concerns the gene COL1A1 and hydrops fetalis.