CDK8 and Familial prostate cancer: Moreover, the involvement of CDK8 in the pathogenesis of gastric cancer, breast cancer, prostate cancer, melanoma, and acute myeloid leukemia highlights its potential as a promising therapeutic target for various malignancies (Kapoor et al., 2010; Broude et al., 2015; Nitulescu et al., 2017; Offermann et al., 2022; Xu et al., 2023).