PRKCA and non-small cell lung carcinoma: In addition, in NSCLC cells, when the CDK8 kinase module is structurally intact, the physical interaction between the modules is weakened due to the silencing of MED13L, which ultimately inhibits the expression of the oncogene PRKCA, resulting in the sensitivity of NSCLC cells to radiotherapy (Zhang et al., 2020) (Figure 3).