Nevertheless, a recent report indicates that the majority of SSc-ILD patients who tested positive for anti-Ro/SSA52 exhibited a significant enrichment of anti-Ro/SSA52 antibodies in their BAL fluid, with a ratio exceeding 50 times (11), suggesting a potential pathological role of Ro-52 antibodies in pulmonary pathology. This evidence concerns the gene CALR and interstitial lung disease.