The lung cancer was stable, meanwhile the esophageal lesion was almost cured.<h4>Conclusion</h4>Icotininb is an effective treatment in the patients of the double primary malignant tumors of lung adenocarcinoma with EGFR gene mutation and esophageal squamous cell carcinoma with EGFR over-expression. Here, EGFR is linked to esophageal squamous cell carcinoma.