In the group with high expression, RPS6KA1 might activate fatty acid metabolism, lipid and atherosclerosis, and TNF signaling, chemokine signaling, and focal adhesion pathways (Figures 8A-F), whereas SERPINA3 might activate NF-κB signaling, Toll-like receptor signaling, and FoxO signaling pathways, apoptosis, fatty acid metabolism, lipid and atherosclerosis. The gene discussed is NFKB1; the disease is atherosclerosis.