KISS1 and osteoporosis: Characterized by the loss of bone mass and deterioration of its microarchitecture,1, 2osteoporosis causes disability, reduced quality of life, and increased mortality due to the high risk of serious fractures.3The increasing incidence of osteoporosis, as well as healthcare costs in an aging society, accentuate the need to better understand the physiology and pathogenesis of bone loss.2, 3In this sense, recent studies highlight the importance of reproductive axis molecules in bone physiology, including kisspeptin, during the remodeling of this tissue.