PRKACA and cancer: Based on recent advances in genome sequence analysis (25, 26) that enabled the identification of further cancer entities comprising for example oncocytic neoplasms of the pancreas and bile duct that express the DNAJB1-PRKACA fusion transcript (27) a basket concept was applied for this trial to allow all tumor patients with metastatic disease and evidence of the DNAJB1-PRKACA fusion to participate.