Moreover, Nectin-4 significantly promotes tumor-induced lymphangiogenesis and lymphatic metastasis by regulating the C-X-C motif chemokine receptor 4 (CXCR4)/C-X-C motif chemokine ligand 12 (CXCL12)–lymphatic vessel endothelial receptor-1 (LYVE-1) axis (53).These findings highlight the multifaceted involvement of Nectin-4 in various molecular pathways that contribute to the development and progression of cancer, underscoring its significance as a potential target for cancer therapy and research. Here, CXCL12 is linked to cancer.