ERBB2 and breast cancer: Nectin-4 also enhances p95-ErbB2-induced activation of the JAK–STAT3 signaling pathway (42) and cooperates with p95-ErbB2 to regulate expression of the sex determining region Y-box 2 (SOX2) gene, which in turn regulates the proliferation, survival, and differentiation of cancer cells, thereby enhancing the proliferation of breast cancer T47D cells (52).