Though CD8+ CD20+ T cells from all the studied groups predominantly belonged to the central memory compartment, in HC-MBL a higher amount of CD8+ CD20+ T cells which had undergone differentiation into the effector memory and effector compartments (with a consequent decrease in central memory cells) was observed, compared to both the control group and CLL patients (Figure 5A). The gene discussed is CD8A; the disease is B-cell chronic lymphocytic leukemia.