TNF and Hypertension: CTLs, through the FASL-FAS system, induce apoptosis in target cells (Sanders and Wang, 2002), and their production of cytokines like interferon-gamma (IFNγ) and tumor necrosis factor (TNF) has been linked to hypertension and renal damage in mice models (Sriramula et al., 2008; Saleh et al., 2015).