The variability in the ALOX5 and ALOX5AP genes is associated with carotid intima-media thickness, a marker of carotid atherosclerosis, in patients with type 2 diabetes mellitus [61].While these results suggest an effect of high salt on genes that encode for proteins related to arachidonic acid signaling, they do not provide information on which ones are important in sex differences as it pertains to salt sensitivity. This evidence concerns the gene ALOX5AP and carotid atherosclerosis.