A conditional knock out of Prdm1 (Blimp-1) in murine TREG (Foxp3CrePrdm1fl/fl) generates an increase in the accumulation of TREG cells, accompanied by small increase in TCONV cell abundance that is insufficient to induce autoimmunity (159), confirming Blimp-1 is not essential to the generation, migration or even function of eTREG. This evidence concerns the gene PRDM1 and Autoimmunity.