In this study, the percentage of CD16brightCD62Ldim subtypes to total neutrophils in peripheral blood neutrophils and IL-8 were found to be independent risk factors for the development of infectious complications in patients with sepsis-associated ARDS, and the combination of these two factors can be used to predict the development of infectious complications in patients with ARDS. Here, CXCL8 is linked to acute respiratory distress syndrome.