CXCL8 and neoplasm: However, in oncology studies, high levels of IL-8 in patients have been found to be associated with higher Myeloid-derived suppressor cells (MDSCs) infiltration, poorer T-cell function, and weaker antigen presentation.IL-8 has an inhibitory effect on adaptive immunity, affecting antigen presentation and effector T-cell activity, and tumor-derived IL-8 has also been associated with infiltration of polymorphonuclear neutrophil (PMN)- Myeloid-derived suppressor cells (MDSCs) (21).