We next compared the phenotype and function of CD4+ and CD8+ T cells specific to CCCs/SARS-CoV-2 cross-reactive epitopes in unvaccinated asymptomatic COVID-19 patients, with little to no disease, versus the unvaccinated severely ill COVID-19 patients and the unvaccinated COVID-19 patients with fatal outcomes. The gene discussed is CD4; the disease is COVID-19.