These results extend previous reports on the presence of specific repertoires of protective clones of memory CD4+ and CD8+ T cells in UPPHI possibly primed by previous exposure to seasonal CCCs infections and the rapid recall of α-CCCs/SARS-CoV-2 cross-reactive memory CD4+ and CD8+ T cells (1, 21, 41, 43, 62–66). This evidence concerns the gene CD4 and infection.