To this end, we determined the percentage of unvaccinated asymptomatic COVID-19 patients, unvaccinated severely ill COVID-19, and unvaccinated patients with fatal outcomes who presented significant IFN-γ+CD4+ and IFN-γ+CD8+ T-cell responses (i.e., IFN-γ-ELISpot SFCs > 50) specific to α-CCCs/SARS-CoV-2 cross-reactive epitopes. This evidence concerns the gene CD4 and COVID-19.