CD4 and COVID-19: Next, we determined whether (i) the higher rates of co-infection with α-CCC species observed in the unvaccinated asymptomatic COVID-19 patients were associated with high frequencies of CCCs/SARS-CoV-2 cross-reactive CD4+ and CD8+ T cells detected in these asymptomatic COVID-19 groups and (ii) the high frequencies of α-CCCs/SARS-CoV-2 cross-reactive epitope-specific CD4+ and CD8+ T cells were associated with fewer symptoms observed in unvaccinated COVID-19 patients.