We first compared SARS-CoV-2-specific CD4+ T-cell responses in unvaccinated asymptomatic COVID-19 patients (those individuals who never develop any COVID-19 symptoms despite being infected with SARS-CoV-2) to unvaccinated symptomatic (those patients who developed severe to fatal COVID-19 symptoms) (Figure 1). The gene discussed is CD4; the disease is COVID-19.