This cluster includes gene sets such as “Senescence-Associated Secretory Phenotype (SASP) (R-HSA-2559582)”, “Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (R-HSA-75035)”, and “G2/M DNA damage checkpoint (R-HSA-69473)”, indicating the presence of enhanced DNA damage and the DNA damage response (DDR), as well as subsequent senescence induction in SLE monocytes (Figures 1B, C). Here, CDS1 is linked to systemic lupus erythematosus.