This cluster includes gene sets such as “Senescence-Associated Secretory Phenotype (SASP) (R-HSA-2559582)”, “Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (R-HSA-75035)”, and “G2/M DNA damage checkpoint (R-HSA-69473)”, indicating the presence of enhanced DNA damage and the DNA damage response (DDR), as well as subsequent senescence induction in SLE monocytes (Figures 1B, C). The gene discussed is CHEK2; the disease is systemic lupus erythematosus.