Gene set enrichment analysis (GSEA) also showed enrichment of genes for “Cellular senescence (R-HSA-2559583)” and “Senescence-Associated Secretory Phenotype (SASP) (R-HSA-2559582)” in SLE monocytes (Figure 1D), suggesting enhanced cellular senescence in STING pathway-activated SLE monocytes. This evidence concerns the gene STING1 and systemic lupus erythematosus.