HIF1A and obstructive sleep apnea syndrome: Meanwhile, scholars have attempted to establish a bridge connecting the pathophysiological link between OSA and lung cancer and have confirmed that IH, which is associated with OSA, results in the overexpression of some signaling molecules that promote cell proliferation by activating the HIF-1α signaling pathway, which further activates downstream signaling pathways (including inflammation, cell proliferation, and neovascularization).