CD274 and obstructive sleep apnea syndrome: showed that IH-induced PD-L1/PD-1 overexpression in patients with severe OSA reduced autologous T cell proliferation and cytotoxic activity of CD8+T cells, increased recruitment of myeloid-derived suppressor cells, and showed an increase in PD-L1 on monocytes and PD-1 on CD8+T cells in patients with OSA (63).