Meanwhile, by measuring the levels of HIF-1α and ATPase family AAA structural domain-containing protein 2 (ATAD2)-associated genetic products in A549, H460, H1299, and SPC-A1 cells, which are the representative NSCLC cells, the levels of ATAD2-related mRNA and protein levels were found to be significantly elevated in the IH+NSCLC model. This evidence concerns the gene HIF1A and non-small cell lung carcinoma.