HK2 and GBE1 are located downstream of the HIF-1α signaling pathway, and their expression was positively correlated with tumor size, primary tumor stage T, and tumor lymph node stage N. Meanwhile, higher expression of HK2 and GBE1 has also been shown to affect OS in lung adenocarcinoma but not squamous lung cancer (99). This evidence concerns the gene HIF1A and neoplasm.