In a multicenter observational study, 360 patients with cutaneous melanoma were enrolled, and serum soluble programmed death ligand 1 (sPD-L1) levels were measured, which showed that sPD-L1 levels were higher in patients with severe OSA than in those with non-severe OSA and those with non-OSA (62). This evidence concerns the gene SPDL1 and cutaneous melanoma.