Secretion of epidermal growth factor (EGF), platelet-derived growth factor (PDGF), IL-6, IL-8, and IL-10 and activation of the Wnt/β-catenin signaling pathway by TAMs can directly induce tumor cell proliferation (29, 30), while secretion of metalloproteinases (MMPs), growth factors, and angiopoietin-1 promotes angiogenesis to provide nutrient and oxygen support (31, 32). This evidence concerns the gene EGF and neoplasm.