Givne that, to our knowledge, there were no previous reports on whether TLR7 engagement ( a lupus-relevant pathway) would induce ACOD1, we performed an in vitro time-course on WT and Acod1−/− bone marrow-derived macrophages (BMDM) following incubation with IMQ. Here, TLR7 is linked to systemic lupus erythematosus.