Some of the benefits of small hairpin RNAs (shRNAs) processing that is not dependent on DICER include the ability to target genes in tumor cells that lack DICER and the preferential loading of small interfering RNAs (siRNAs) into AGO2, which improves RNAi (Herrera-Carrillo and Berkhout, 2017). The gene discussed is DICER1; the disease is neoplasm.