TMEM209 is a putative ortholog to the S. cerevisiae NPC membrane ring protein ScPom34 [138] which interacts with the NPC in lung cancer cells [139], shows colocalization with the NPC and has been suggested as an additional NPC component [140], while PNET1 is a membrane ring nucleoporin [141]. The gene discussed is TMEM209; the disease is lung carcinoma.