Cytokine profiling confirmed the reduction in immunosuppressive TANs upon chitin treatment, showing significantly reduced levels for MIP-2/CXCL2, an IL-8 orthologue and neutrophil chemoattractant, in chitin-treated 66cl4 primary tumor lysates and a reductive trend in chitin-treated 4T1 primary tumor lysates (Fig. 5M,N). Here, CXCL2 is linked to neoplasm.