Yet, the Ly6G+ nature of prominent CLP producers at least provides an explanation for the heterogeneity in CLP production between the 4T1- and 66cl4-based model: whereas the 4T1-based model is characterized by high numbers/percentages of PMN-MDSCs and TANs in its TME and concomitant G-CSF and MIP-2 primary tumor levels, the 66cl4-based model has only low numbers/percentages of both granulocytic subpopulations and related cytokine levels in its primary tumors. This evidence concerns the gene CXCL2 and neoplasm.