CHIA and cancer: Of note, although their function in the context of cancer remains unclear, it should be mentioned that enzymatically active mammalian chitinases, including acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1), are also known targets of chitin [6] and could potentially contribute to the observed treatment effects in the 4T1- and 66cl4-based model for TNBC.