Additionally, all tumor tissues clustered within pHGG H3-/IDH-wt RTK1 subtype in t-SNE analysis based on DNA methylation status, although Cases 1 and 2 did not exhibit significantly high calibrated scores for pHGG H3-/IDH-wt, RTK1 subtype using DKFZ classification system. Here, IDH2 is linked to neoplasm.