Tian et al. reported six IDH-mutant glioma cases and 13 IDH-wildtype glioma cases that developed in adult patients with LFS in a Chinese cohort, including three cases with EGFR mutation or amplification, and six cases with PTEN mutation, implicating glioblastoma, IDH-wildtype [25]. This evidence concerns the gene IDH2 and glioblastoma.