In conclusion, ESCO2 is a potential biomarker and oncogene for pan-cancer that can accurately predict the cancer patient’s prognosis in ACC, KICH, KIRC, KIRP, LGG, LIHC, LUAD, MESO, PAAD, THYM, COAD, and READ. Here, ESCO2 is linked to adrenal cortex carcinoma.