In 2018, Dai Jianwu and Sun Haixiang’s team found that collagen-loaded umbilical cord mesenchymal stem cells could activate primordial follicles in vitro by phosphorylating FOXO3a and FOXO1, and also increased estradiol concentration and the number of antral follicles in vivo to save the overall function of the ovaries of POF patients with long-term infertility [29]. This evidence concerns the gene FOXO1 and premature menopause.