CDK7 and cancer: Consequently, the targeting of transcription regulators like CDK7 has emerged as a strategy to dismantle this transcription boost [60], with THZ1 and THZ2 showing particular efficacy against cancers that rely on SE-driven genes including C-MYC, RUNX2, STAT, SOX2, MITF, SOX9 [32, 33, 48, 49, 61–64].