However, HOXA9 regarded as the “switch” of cell proliferation in the process of myeloid leukemia, which can promote the expression of CDK6, CyclinD1 gene and telomerase RNA by triggering pleiotropic oncogenes Myc and Myb, and provide necessary cofactors to maintain the rapid proliferation of cells [46]. The gene discussed is CDK6; the disease is myeloid leukemia.