Therefore, this study mainly screened the independent risk factors for brain metastasis in NSCLC patients from the clinical data, tumor markers, EGFR mutation status, PET/CT imaging omics and PET quantitative indexes of lung adenocarcinoma patients, and evaluated the efficacy of six machine learning prediction models for lung adenocarcinoma brain metastasis based on 18 F-FDG PET/CT radiomics combined with EGFR. This evidence concerns the gene EGFR and lung adenocarcinoma.