In this study, the rate of brain metastasis in EGFR mutation-positive patients was 69.7%, which was an independent risk factor for brain metastasis of lung adenocarcinoma, and EGFR-positive patients with adenocarcinoma were 2.905 times more likely to develop brain metastasis than EGFR-negative patients. Here, EGFR is linked to lung adenocarcinoma.