However, these studies were founded in cells lacking high levels of MYC and as WDR5 is a critical cofactor for c- and N-MYC [13, 14] target gene recognition, it is worth understanding the extent by which MYC, PDPK1, and WDR5 influence expression of mitotic genes in a more relevant MYC-driven cancer context. Here, PDPK1 is linked to cancer.