For instance, phenotypes caused by mutations in the iBMF genes Fancd2 and Rps14 (Ceccaldi et al, 2012; Barlow et al, 2010) or in the microcephaly-related genes Aspm, Cep63, and Cenpj (Williams et al, 2015; Phan et al, 2021; Insolera et al, 2014) are rescued by the inactivation of p53 whereas congenital anemia and microcephaly caused by the inactivation of Cdk5rap2 (Tátrai and Gergely, 2022) or Cep135 (MCPH8) (González-Martínez et al, 2022) genes are not. This evidence concerns the gene FANCD2 and microcephaly.