In our study, we employed MR analysis to investigate potential causal associations between the risk of liver cancer and several modifiable risk factors, including abdominal obesity (measured by waist circumference), overall obesity (measured by BMI), T2DM, lifestyle factors (such as smoking, alcohol consumption, and coffee intake), glycemic traits (such as 2-h glucose, FI, FG, and HbA1c), and lipoprotein traits (such as HDL, LDL, TC, TG, APOA-I, and APOB). The gene discussed is APOA1; the disease is liver cancer.