In response to iron deficiency, proteins IRP1 and IRP2 bind to IREs within the 5ʹ untranslated region (UTR) of specific mRNAs, including ferritin H and L (FTH1 and FTL1), ferroportin (FPN1), and hypoxia inducible factor 2α (HIF2α), blocking their translation13. The gene discussed is SLC40A1; the disease is Iron deficiency anemia.