For DSS, high expression of SPC25 was a negative factor in ACC (p < 0.001), KICH (p < 0.001), KIRC (p < 0.001), KIRP (p < 0.001), LIHC (p < 0.001), LUAD (p < 0.001), MESO (p < 0.001), PARAD (p < 0.001), and UCEC (p < 0.001) patients, but a positive factor in DLBC patients (p = 0.040) and STAD (p = 0.008). The gene discussed is SPC25; the disease is adrenal cortex carcinoma.