Consistent with the results of the Cox proportional hazards model of DSS, the K-M curve indicated that a high level of SPC25 was positively correlated with good survival outcomes in STAD (p = 0.002), and COAD (p = 0.031), and negatively correlated with survival in ACC (p < 0.001), KIRP (p < 0.001), LUAD (p < 0.001), MESO (p < 0.001), LIHC (p = 0.003), UCEC (p = 0.002), and KIRC (p = 0.003) (Supplementary Fig. 3). Here, SPC25 is linked to adrenal cortex carcinoma.