Kaplan–Meier analysis showed that high expression of SPC25 predicted poor OS in ACC (p < 0.001), KIRC (p = 0.006), KIRP (p < 0.001), LIHC (p < 0.001), LUAD (p = 0.003), MESO (p < 0.001), and UCEC (p = 0.003), while high SPC25 predicted better OS in THYM (Fig. 2D , p= 0.018), CESC (p = 0.022), STAD (p = 0.044), and THYM (p = 0.018) (Fig. 3). This evidence concerns the gene SPC25 and adrenal cortex carcinoma.