SPC25 and cancer: The differential analysis of SPC25 based on cancer and pan-cancer tissue samples from the TCGA and TIMER2.0 database indicated that SPC25 had higher expression in cancer tissues than paraneoplastic tissues such as BLCA BRCA, CESC, CHOL, COAD, ESCA, GBM, HNSC, KIRC, KIRP, LIHC, LUAD, LUSC, PRAD, READ, STAD, THCA, and UCEC (Fig. 1A).