TIMP1 and schizophrenia: Therefore, male patients with TRS and CMS were recruited to determine (1) whether there are differences in OS parameters, MMP-9, and TIMP-1 between schizophrenia patients and healthy controls; (2) whether alterations to OS parameters, MMP-9, and TIMP-1 are related to the severity of clinical symptoms; (3) whether serum MMP-9 or TIMP-1 and plasma OS parameters levels are independently or interactively correlated with the clinical features of schizophrenia patients; and (4) whether OS parameters and MMP-9 and TIMP-1 levels are predictive of the prognosis of TRS.