Enhancer of zeste homolog 2 (EZH2) methylated FOXA1 at Lysine-295 and enhanced the deubiquitination of FOXA1 by ubiquitin-specific protease 7 (USP7), which maintained the stability of FOXA1 protein and promoted the growth of PCa [155]. This evidence concerns the gene USP7 and posterior cortical atrophy.