Mechanistically, upregulated FOXA1 activates the metastatic transcriptional program by driving super-enhancer (SE) reprogramming and recognizes hypoxia-inducible transcription factor (HIF-2a) as a target of FOXA1-induced SE, mediates the expression of metastatic genomes in endocrine-resistant breast cancer cells, and induces proliferation, migration, and invasion of breast cancer cells [161]. Here, EPAS1 is linked to breast carcinoma.