Mechanistically, FOXA1 inhibits its expression by binding to the interleukin 8 (IL-8) promoter, and when FOXA1 expression is decreased or absent, IL-8 up-regulation activates the MAPK/ERK pathway, leading to ERK phosphorylation and enolase 2 (ENO2) expression to promote NE differentiation in PCa cells [92]. This evidence concerns the gene CXCL8 and posterior cortical atrophy.