SNAI2 and posterior cortical atrophy: Consistent with this result, microRNA-194 (miR-194) was negatively correlated with AR signaling in PCa treated with AR inhibitors, and miR-194 upregulated the expression of the chemokine IL-8 and the EMT transcription factors SNAI2 and ZEB1, which can promote the NE phenotype in PCa, by targeting and inhibiting the expression of the downstream gene FOXA1 [93].