FOXA1 and FOXA2 regulate the hypoxic transcriptional program inversely when PCa is in a hypoxic tumor microenvironment, and which of FOXA1 and FOXA2 tends to regulate HIF1A may depend on the high or low expression of FOXA1 and FOXA2 in the PCa phenotype. Here, HIF1A is linked to posterior cortical atrophy.