JAG1 and coloboma: Coloboma mutant mice were first described by Searle et al., developed through irradiation caused by a mutation on chromosome 2 [108] and reported to be mutated by approximately 20 genes [109–111] such as: phospholipase C beta-1 (Plcb1), jagged 1 (Jag1), and synaptosomal-associated protein 25 kDa (Snap25).