For the genes previously reported to be associated with intestinal differentiation or Barrett’s esophagus (HMGA1, EPHB2, and OLFM4) the protein-to-RNA ratios were similar between normal tissues and EAC, suggesting regulation of protein abundance is constant for these genes during the development of EAC from Barrett’s esophagus. Here, OLFM4 is linked to esophageal adenocarcinoma.