In our study, CTLA4+ T cells, IL1RL1+ T cells, and LAG3+ T cells identified in tumor tissues specifically overexpressed CTLA4, IL1RL1, and LAG3, respectively, which indicated that T Cells in HCC might be in the state of inhibition of activation or depletion of function, and were unable to properly achieve anti-tumor-related killing function. Here, CTLA4 is linked to hepatocellular carcinoma.