CNTNAP2 and autoimmune encephalitis: The frequency of relapses in LGI1-Ab encephalitis varies greatly in the literature, from 13%4 to 35%,2 and even up to 59% in a mixed cohort including patients with contactin-associated protein-like 2 antibodies.1 On one hand, relapses have been heterogeneously defined in the past, likely leading to a misperception regarding their true frequency1,4,6,8, -, 10; on the other hand, patients with autoimmune encephalitis may experience transient fluctuations of symptoms early in the disease course,13 often due to suspension or dose decrease of immunosuppressive treatment.