The frequency of relapses in LGI1-Ab encephalitis varies greatly in the literature, from 13%4 to 35%,2 and even up to 59% in a mixed cohort including patients with contactin-associated protein-like 2 antibodies.1 On one hand, relapses have been heterogeneously defined in the past, likely leading to a misperception regarding their true frequency1,4,6,8, -, 10; on the other hand, patients with autoimmune encephalitis may experience transient fluctuations of symptoms early in the disease course,13 often due to suspension or dose decrease of immunosuppressive treatment. This evidence concerns the gene CNTNAP2 and encephalitis.