This is of major importance because a significant number of patients with LGI1-Ab encephalitis report cognitive sequelae,9,12,21 although the underlying causes are still incompletely understood, perhaps involving hippocampal atrophy,22,23 disrupted connectivity,24,25 or reduced cognitive reserve.26 Thus, given the elevated disability and the higher risk of relapses, patients with cognitive sequelae should be closely monitored. Here, LGI1 is linked to hippocampal atrophy.