We reported for the first time that miR-132-3p inhibited the production of extracellular matrix proteins activated by TGF-β1/Smad2/3 signaling pathway during the formation of PF, and we found the similar relationship between miR-132-3p and PF in vitro and in vivo, and even in humans. This evidence concerns the gene TGFB1 and pemphigus foliaceus.