Notable lncRNAs of the yellow module (decreased in SR, then increased after regorafenib) include the oncogenic molecules CHRM3-AS2 [48] and DLX6-AS1 [49] as well as AL137127.1, AC020978.3 and LINC01242, which are thought to promote chromatin remodeling in HCC [50, 51]. The gene discussed is CHRM3; the disease is hepatocellular carcinoma.