Interestingly, the median fraction of spike specific CD4+ T cells was significantly higher in aviremic PLWH than the HIV-uninfected participants, perhaps indicative of a different SARS-CoV-2 course of infection in PLWH [27] or interactions of SARS-CoV-2 immunity with HIV-mediated partial immune activation in HIV suppressed PLWH [61]. Here, CD4 is linked to infection.