Serum concentrations of Nostrin, NGAL and KIM-1 were compared between patients with versus without any of the following pre-existing morbidities: arterial hypertension, coronary artery disease (CAD), diabetes mellitus, heart insufficiency, history of neoplasia, chronic kidney disease, pulmonary disease or obesity. The gene discussed is HAVCR1; the disease is obesity due to melanocortin 4 receptor deficiency.