Third, platelets activated during lung injury could be aggregated and be overactively involved in microthrombus formation.26 On the other hand, the underlying mechanism for the decreased absolute lymphocyte count is that SARS-CoV-2 triggers pyroptosis in lymphocytes through the activation of NLRP3 inflammasome.26 Furthermore, another hypothesis points out the role of the proinflammatory cytokine IL-6 that utilizes the lymphocytes; hence, decreased lymphocyte counts are associated with poor prognosis in COVID-19 patients. This evidence concerns the gene IL6 and COVID-19.