Sexual dimorphic actions of inflammasomes were not unprecedented as uneven severity of atherosclerosis was found in male and female Nlrp3-deficient mice with gonadal insufficiency (Chen et al., 2020) and sex-dependent differential activation of AIM2 and NLRP3 inflammasomes in macrophages from systemic lupus erythematous had been reported (Yang et al., 2015). Here, AIM2 is linked to atherosclerosis.