Chica et al. found positive staining of several cell populations of normal bone marrow but not in megakaryocytes, except for weak staining near the cell membranes [15], while Åström et al. [14] reported cytoplasmic positivity for CCN2 in a subpopulation (18%) of megakaryocytes in 1 of 5 patients with X-linked thalassemia in almost all (97%) megakaryocytes of all 6 primary myelofibrosis patients, while other hematopoietic cell lineages and the megakaryocytes in normal control BM biopsies were negative [14]. Here, CCN2 is linked to myelofibrosis.