A lack of correlation between CCN2 expression and BM fibrosis is remarkable, especially because the prototypical fibrosis inducer TGF-β, known to also contribute to myelofibrosis in MPN [19], is a potent inducer of CCN2, the two forming a positive feedback loop [4–8]. The gene discussed is TGFB1; the disease is myeloproliferative neoplasm.