Although CCN2 overexpression was specifically observed in megakaryocytes, no correlation was observed between the level of CCN2 expression and the platelet counts or occurrence of thrombovascular events in this small subgroup, but additional studies on larger cohorts of MPN patients will be needed to better investigate the possible meaning of the megakaryocytic CCN2 overexpression in the development or complications of MPN. The gene discussed is CCN2; the disease is myeloproliferative disorder.