CCN2 and acute myeloid leukemia: In addition, altered CCN2 mRNA expression levels have been associated with BM malignancies: in B-acute lymphoblastic leukemia, increased CCN2 mRNA levels are present in B-lymphoblasts, whereas in acute myeloid leukemia, CCN2 mRNA overexpression has been detected in the mesenchymal stem/stromal cells [11, 12].